PIPELINE

Immuno-oncology Platform

Cellemedy develops innovative treatment of cancer for better health for human world-wide
Human Ferritin – Iron-free 24mer of H- & L-chain

Human Ferritin

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Iron-free 24mer of H- & L-chain

Human Protein Stable at High Temperature and at pH 4-10.

Excellent Human Body Suitability and Stability with Low Inflammatory Response and Immunogenicity.
(PNAS 2014, 111:13900 / Intern. Emerg. Med. 2006, 1:187 / ACS Nano2014, 7:4830 / Front.Chem. Sci. Eng. 2017, 11:633)

Development of Immune Checkpoint Inhibitors
and Cancer Vaccine based on Human Ferritin with Low Immunogenicity

1st. Generation

Chemotherapy

Cancer Cure

Attacks Cells Indiscriminately

2nd. Generation

Target Cancer Therapy

Cancer Target Cure

Limited Cancer Cure Effect

Drug Resistance

3rd. Generation

Immunotherapy

(Vaccine, Immune Checkpoint Inhibitor)

Wide Range Cure Effect

Patient Specific

Cure Metastatic and Recurrent Cancer

Drug Resistance

Side Effect

Difficult to Cure Drug Resistance

High Cost and Long Development Time

Promotes Cancer-specific Immune Cells

Low Immunity Effect by Antigen

Adjuvant Toxicity

새로운 플랫폼 + 우수한 약물 효능 + 낮은 부작용

‘Innovative Strategy’ using
huHF Platform

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Synergy of Immune Checkpoint Inhibitor and Cancer-cure Vaccine : Next Generation Immunotherapy.

  • Human Ferritin(huHF) Platform for of Immune Checkpoint Inhibitor and Cancer-cure Vaccine

  • Excellent Cancer-cure Effect by Synergy of Immune Checkpoint Inhibitor and Cancer-cure Vaccine

    ㅣImmune Checkpoint Cure: Comparing to Existing Antibody Cure

    · Excellent Cure Effect

    · Low Immunogenicity

    · Lower Drug Resistance

    ㅣCancer-cure Vaccine

    · Efficient T-cell Boosting Effect

    · No Adjuvants Needed(No Side Effects)

  • Low Manufacturing Cost

    Better Accessibility for Patients

Synergy – Vaccination + IC therapy
(melanoma (B16F10))

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Combination therapy schedule

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Days after tumor challenge

Cellemedy Pipeline

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  • Cancer Immunotherapy

    ㅣplatform - Human Ferritin Platform

    · Bi-specific Immune Checkpoint Blocker

    · Efficient Carrier for Antigen

    ㅣSynergy of Immune Checkpoint Inhibitor and Cancer-cure Vaccine

    ㅣSolution for Existing Immunotherapy

    · Cooperation with Korea University